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The Times - Correction   4/2/2010

Although the General Medical Council found that Professors Simon Murch and John Walker-Smith, former colleagues of Andrew Wakefield, had failed in their duties as responsible consultants such that they continue to face charges of serious professional misconduct ("Fall of 'dishonest' doctor who started MMR scare", January 29), it did not find them dishonest or, in the case of Professor Murch, irresponsible, contrary to our report. We were also wrong to say (“The men who started the scare”, same day) that they had not retracted the claim that MMR could be linked to health problems; they did so in The Lancet in 2004. We apologise for the errors.


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GMC FINDING ON FACT – 28 JAN 2010

DR WAKEFIELD AND PROFESSORS MURCH AND WALKER-SMITH

A STATEMENT FROM PARENTS OF AUTISTIC CHILDREN TREATED BY THE THREE DOCTORS

The GMC was WRONG to find the doctors guilty on the findings of fact when no parent or patient was a complainant in this fitness to practice hearing. The Panel has chosen the facts it wants, and rejected those it doesn’t want, to find the doctors guilty on fact – facts that go back 16 years.

The evidence

Parents heard the doctors put up a robust defence. Documents and evidence produced by the doctors showed

  • the 1995 ethics committee letter granting approval for the Lancet research was produced
  • the research followed the terms of the approval given
  • the Lancet editor knew that Wakefield was doing a separate legal aided study
  • all the children were on the autistic spectrum
  • the children were recruited as described in the Lancet paper
  • the use of invasive interventions – colonoscopies, etc – was clinically justified
  • no child was harmed; no parent refused consent; no parent complained

However, the GMC chose to ignore the 1995 ethical approval and substitute a 1996 approval, allowing them to reach the findings they did – a blatant disregard for justice. They also insisted that ‘pervasive developmental disorder’ was not the same as autism spectrum disorders which of course it is; and that only children who had had the measles or measles/rubella vaccine should have been admitted onto the project, not those who had had the MMR. The hearing moved the goalposts so that the doctors had no chance of overturning the serious charges against them.

The injustice

This is the same GMC that missed Harold Shipman, the Bristol babies and Alder Hey. We believe it has made another blunder.

This scandalous show trial was used to mask real concerns parents have about why their children regressed into autism following MMR. The GMC and government engaged in a callous and diversionary tactic to end speculation about MMR safety and ensure scientific research into autism and bowel disease, and the role of vaccines, ended.

Parents’ requests that this research should continue fell on deaf ears. At the same time the numbers of autistic children has risen thirty-fold since the MMR was introduced in 1988 amidst the parents’ constant pleas for research into why their children were damaged. What role vaccines play in our children’s deaths (in some cases), seizures, regressive autism, bowel disease, daily pain and disability must be investigated.

The effects of the GMC hearing are to warn off doctors from expressing similar concerns about one size fits all vaccination policy and to ensure that scientists won’t investigate vaccine safety. The effect is to ensure government contracts with the large drug-makers are safeguarded and that clauses compelling government to make good their loss of earnings should MMR sales drastically fall are not activated. The commercial interests of the drug-makers take priority over research into why autism has increased dramatically.

The plan has been to “discredit” the doctors and ensure they are left undefended in the media. The press have been compelled to refer to their “discredited” work. But scientists claiming this have never fully replicated their work; the doctors’ research remains original and significant.

Independent research into why autism has increased must be funded, without powerful drug makers influencing the research agenda to keep share prices high and protect their products.

Please voice your support for the doctors with the CryShame Facebook Group…

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...and, if you haven't already done it, sign the Nigel Thomas Petition.

CryShame

Cryshame is a pressure group made up of parents who saw their children regress into autism after the MMR jab. Cryshame wholeheartedly supports the three doctors, Dr Andrew Wakefield, Professors Simon Much and John Walker-Smith, each an expert in paediatric gastroenterology – Professor Walker-Smith an expert of world class.

In 1998 the three doctors published a small peer-reviewed investigation in The Lancet of 12 children with autism and painful bowel disorders – the subject of the GMC hearing. They followed this with other peer-reviewed publications of larger samples of autistic children and controls. Their findings have been replicated in published research in other parts of the world. But since GMC’s case began research in the UK was halted. In 2006 only £1m was spent on autism research in the UK. Yet the numbers of children with autism reached 1 in 66 in 2009, from one in 2000 in 1987 – a thirty-fold increase during the period since when MMR was introduced. 

We believe that eventually this so far unstoppable increase will force a rethink on the role of vaccination. All the US Presidential candidates in 2008 committed to funding research into vaccines and autism.  

This whole episode has been driven by the government and the GMC's desire to vilify the doctors and discredit their work. Despite their robust defence, the costs to the doctors and their patients have been immense:

  • their clinical practice and research has been put on hold to the detriment of the many children with bowel disease, including but not only autistic children
  • research into the role of vaccinations in the onset of autism and bowel disease has been suspended in the UK to the detriment of children who became autistic following the MMR jab, in some cases within days
  • despite many parents seeing their children regress into autistic after the MMR jab, few doctors or medical scientists have investigated this pattern of possible causality. However anecdotal, this pattern is significant and demands investigation given continuing scientific ignorance of what is causing the growing epidemic of autism
  • the majority of scientists who have investigated the link between autism and MMR focus on discrediting Wakefield . They offer no new findings about why a growing number of children are becoming autistic. For these scientists this alarming fact –   with untold consequences for society patients and parents – remains unremarkable
  • the hearing was used to discourage research into vaccine safety by publicly vilifying the exemplary character of three doctors to discourage other medical scientists from investigating vaccine safety

 Background Notes

1.  The length of time between the events on which the charges are based and the time of the GMC hearing was up to 16 years, so eroding the   witnesses' memory of the original events and the availability of key documents lost or destroyed in the intervening years

2.  The hearing is the longest and most expensive hearing in the GMC's history. Estimated at over £10m, this money could have been spent on  autism research

3.  None of the children or their parents referred to by the prosecuting counsel was a complainant in this hearing. No parent lodged a complaint against the three doctors. Indeed parents supported the doctors throughout the hearing.

4.  None of the children and parents cited at the hearing was legally represented. There was no attempt to secure representation for them

5.  One of the initial complainants/informants in February 2004 was a journalist who continued to publish articles on the defendants in the Sunday Times without revealing his interest in the case

6.  The parents believe the hearing was a witch-hunt conducted by government, the GMC and pharmaceutical interests to discredit the doctors, to ensure they are ‘struck off' and cannot practice, and to discourage medical scientists from conducting independent research into vaccine safety

7.    In 2002, Wakefield et al found measles virus in the bowel of 75 out of 91 autistic children who had had MMR but not wild measles , but rarely in the controls ( Uhlmann et al, ‘Potential viral pathogenic mechanism for new variant inflammatory bowel disease', Jnl of Clinical Pathololgy : Molecular Pathology, 55)

8.    The only study to partially replicate Wakefield's 2002 study and arrive at different findings studied only five children (out of a total of 25) who had received MMR before onset of autism and bowel disease, compared with 75 such children in the 2002 ( Hornig et al (2008) ‘ Lack of Association between Measles Virus Vaccine and Autism with Enteropathy : A Case-Control Study', P losone )

9.    Wakefield’s work has not been fully replicated and therefore it has not been discredited

 


An open letter to Jeremy Laurance,
Health Editor of The Independent

John Stone 7 January 2010

Laurance [1] writes:

"One of the greatest puzzles of the saga is what has sustained this level of mistrust in the medical authority."

It may seem like this to a newspaper jounalist, not paying enough attention to the small print, but it does not seem like this to many autism parents. One of the features of this episode is the reverse spin given to studies which actually support further concern.

For instance, a widely reported study by Hornig et al 'Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study' actually immeasurably enhanced the plausibility of the Wakefield hypothesis by showing the persistance of measles virus in the ileum of two patients (one autistic, one control, but both with bowel disease and having had MMR) confirmed in 3 laboratories. To cap it all in the discussion the authors stated:

"Our results differ with reports noting MV RNA in ileal biopsies of 75% of ASD vs. 6% of control children [10]... Discrepancies are unlikely to represent differences in experimental technique because similar primer and probe sequences, cycling conditions and instruments were employed in this and earlier reports; furthermore, one of the three laboratories participating in this study performed the assays described in earlier reports. Other factors to consider include differences in patient age, sex, origin (Europe vs. North America), GI disease, recency of MMR vaccine administration at time of biopsy, and methods for confirming neuropsychiatric status in cases and controls."

thus, quietly endorsing the results of the Uhlmann (O'Leary/Wakefield) study [2,3]. These anomalies were not picked up or reported by mainstream journalists.

Another key case is the Cochrane review of MMR 2005 [4], which actually gave a poor review to the six autism studies included, and found little evidence for the vaccines safety - indeed, had found the safety studies to be "largely inadequate" - against which the claim that it had not found any evidence that MMR causes autism and bowel disease has to be assesed for its relevance [5].

Meanwhile, a Cambridgeshire study of autism in children detected an incidence of ~1 in 60 [6], a result which the Observer newspaper was pilloried for reporting by Ben Goldacre and the lead author Simon Baron Cohen, ahead of the GMC hearing against Wakefield and colleagues [7], but which later turned out to be well-founded.

Whatever happens at the GMC, I suggest, the greatest gap in credibilty lies with a scientific profession which has failed to explain what is happening to our children.

 

[1] Jeremy Laurance, 'Health stories of the decade', http://www.bmj.com/cgi/content/full/339/dec10_4/b5281

[2] Hornig et al, 'Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study', http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526159/

[3] Uhlmann et al, 'Potential viral pathogenic mechanism for new variant inflammatory bowel disease',http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187154/

[4] Demicheli et al, 'Vaccines for measles, mumps and rubella in children', http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD004407/frame.html

[5] John Stone, 'Re: Evidence is not bullying', http://www.bmj.com/cgi/eletters/339/sep09_1/b3658#220537

[6] Baron-Cohen et al, 'Prevalence of autism-spectrum conditions: UK school-based population study', Br J Psychiatry. 2009 Jun;194(6):500- 9,http://www.ncbi.nlm.nih.gov/pubmed/19478287

[7] Ben Goldacre, 'MMR: the scare stories ar back', http://www.bmj.com/cgi/content/full/335/7611/126

source: http://www.bmj.com/cgi/eletters/339/dec10_4/b5281#228759

 

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